Also known as Stenabolic, SR9009 has been developed by Scripps Research Institute under the leadership of professor Thomas Burris.
In spite of being associated with SARMS, Stenabolic (SR9009) is in fact a Rev-ErbA ligand. It means SR binds to this protein and makes it more active. As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits.
As mentioned beforehand, SR9009 is a synthetic Rev-Erb ligand, which is taken orally. This is a very unique compound. By stimulating the Rev-Erb protein, SR9009 has the ability to greatly influence a lot of regulatory mechanisms in the human body.
For instance, it can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages. Hence, Stenabolic will allow the user to lose fat and drastically increase endurance, both of which are very desirable effects for an athlete.
SR9009, which is currently under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice. Treated mice become lean, develop larger muscles and can run much longer distances simply by taking SR9009, which mimics the effects of aerobic exercise. If similar effects can be obtained in people, the reversal of obesity, metabolic syndrome, and perhaps Type-II diabetes might be the very welcome result.
The drug was developed by Professor Thomas Burris, who found that it was able to reduce obesity in populations of mice. It binds to and activates a protein called Rev-ErbAα, which influences fat and sugar burning in the liver, production of fat cells, and the body's inflammatory response.
Reference
If the effects of SR9009 on mice can safely be reproduced for people, the new drug may offer new therapies for obesity and its companions, metabolic syndrome and diabetes. Another area in which SR9009 or a similar drug may confer substantial benefit is to offset the loss of general muscle conditioning which occurs as a side effect of reduced activity caused by illness and/or aging. People most likely to enjoy these benefits include those suffering from severe arthritis, congestive heart failure, chronic obstructive pulmonary disease (COPD), and other conditions that restrict the ability to exercise.
SR9009 Cas NO.:1379686-30-2
Chemical Names: SR9009; CHEMBL1961796; Ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate; GTPL8901;
Purity:99%+
Molecular Formular: C20H24ClN3O4S
Molecular Weight: 437.94026
Appearance: White fine powder
Solubility: insoluble in water
2D-Structure:
SR9009 (Stenabolic) has the ability to alter the activity of the skeletal muscle mitochondria, or in simple terms – it boosts your metabolic activity. This makes it similar to what DNP does, being SR9009 much safer and not counter-productive to your endurance goals. What’s more, unlike DNP, SR9009 has the ability to mimic actual aerobic exercise without actually putting in the conditioning. Therefore, it will boost your endurance instead of hurting it.
Stenabolic (SR9009) binds to a protein called Rev-erbA. This is important, as this protein influences fat and sugar burning in the liver, production of fat cells, and the body’s inflammatory responses. As a result, this interaction between SR9009 and Rev-erbA allows you to make your current exercise regiment much more effective. In fact, even sitting on your butt all day will not hinder your objectives. All in all, the ultimate goal is to burn off for energy from what you eat, instead of getting it stored as fat, which SR does great. Furthermore, it will attack the existing fat and burn it off.
Stenabolic (SR9009) will help a person become leaner, and it will help them do more distance with cardio without getting winded as fast. Overall, it will increase your VO2 max, allowing you to improve your endurance.
Additionally, SR9009 can benefit non athletes as well, since it can reverse obesity, metabolic syndrome, and type 2 diabetes.
Developers took mice that had low amounts of muscle, low metabolic rate, and had poor running capacity. Hence, the mice were basically human versions of out of shape couch potatoes. Once given Stenabolic, muscle and metabolic rate increased, even without being allowed to exercise. Then, once these mice were allowed to exercise, they were able to run 50% further without getting winded.
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SR9009 treatment was shown to increase endurance and reverse mitochondrial damage in studies.
SR9009 has great promise in increased exercise capacity and endurance. This compound acts as an agonist of Rev-erbα. SR9009 binds to one of the body's natural molecules called Rev-erbα, which influences lipid and glucose metabolism in the liver, the production of fat-storing cells and the response of macrophages (cells that remove dying or dead cells) during inflammation.
Current studies show activation of Rev-erbα with SR9009 led to increased metabolic activity in skeletal muscle in culture,had a 50 percent increase in running capacity, measured by both time and distance.
SR9009 is an easy to dose oral compound that boosts metabolic activity in current studies.
SR9009 latches onto Rev-erbα -- which plays a role in regulating the body's circadian rhythm and metabolism -- resulting in a pronounced metabolic boost in test subjects.
Dosages of 20-100mg a day have been reported by users without any negative side effects. From the information we have received, results from SR9009 treatment appear to be dose dependent up to a maximum dosage of 100mg per day. After this dosage, results tend to taper off.
Dosages of 20-100mg a day have been reported by users without any negative side effects. From the information we have received, results from SR9009 treatment appear to be dose dependent up to a maximum dosage of 100mg per day. After this dosage, results tend to taper off.
Stenabolic should be dosed at 20-30 milligrams (mg) per day and adjusted up or down by 10mg depending on user preference. Regarding the cycle duration, the typical cycle length is 6-8 weeks, and it would be wise to stack SR9009 with Cardarine (GW-501516) for a double dose of endurance power.
There is a big inconvenience with Stenabolic when compared to Cardarine, SR9009 does not have a long half life, so it is must be dosed 3-4 times per day. However, some forum members have had good success dosing it at 2-3 times per day.
The optimal dosages range from 20 to 30 milligrams (mgs) per day. However, there is one drawback - due to a very short half life, you will need to space it out throughout the day for the best balance of the active substance in the body. Thus, it is best to use stenabolic every 2-4 hours, depending on the exact dosage used. For example, when the daily dosage is 30 mgs, you can take 10 mgs every 4 hours.
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